Contact us <\/i> <\/a><\/div>\n[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”ams-breadcrumb-section” _builder_version=”4.21.0″ _module_preset=”5716d3ba-5db9-4c93-9991-e827ac491153″ positioning=”none” custom_margin=”0px||0px||false|false” custom_padding=”1rem||1rem||true|false” border_width_top=”1px” border_color_top=”#e5eaee” border_width_bottom=”1px” border_color_bottom=”#e5eaee” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.21.0″ _module_preset=”9c599c76-b3a9-46a0-86f3-735203d5c098″ custom_margin=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”e6be59c6-62c0-4eac-b5e1-e47041d7be23″ global_colors_info=”{}”][et_pb_sidebar area=”et_pb_widget_area_1″ module_class=”ams-breadcrumbs” _builder_version=”4.21.0″ _module_preset=”default” body_text_color=”#03305D” global_colors_info=”{}”][\/et_pb_sidebar][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.21.0″ _module_preset=”5716d3ba-5db9-4c93-9991-e827ac491153″ custom_padding_tablet=”3rem||3rem||true|false” custom_padding_phone=”2rem||2rem||true|false” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.21.0″ _module_preset=”9c599c76-b3a9-46a0-86f3-735203d5c098″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”e6be59c6-62c0-4eac-b5e1-e47041d7be23″ global_colors_info=”{}”][et_pb_code _builder_version=”4.22.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
Overview<\/h5>\n
Bone is a living organ, and is regularly remodelling. However, in certain clinical and pathological situations, the bone repair process could be impaired or compromised. Bone loss due to trauma or general surgery (tumour resection) along with natural aging process will require reconstructive repair surgery, usually accompanied by bone regeneration.<\/pee>Bone graft substitutes are available as alternatives to autogenous bone for bone repair, bone substitution or bone augmentation and can be derived from biological source (autograft – from patient\u2019s own bone; allograft – from another human donor; or xenograft – from different species (animal or plant); or synthetically made (bone graft substitutes)).<\/pee>Harvesting autograft bone is usually accompanied with postoperative complications, with no guaranteed quality, and may not be readily available with limited supply.<\/pee>Advanced Medical Solutions proposes 2 alternatives from different origins:<\/pee> Synthetic \u2013 MBCP\u00ae<\/sup> Technology<\/pee> Xenogenic \u2013 RESORBA\u00ae<\/sup> Xenogenic Bone Graft (exclusive for dental use)<\/pee>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”ams-bg-light-blue” _builder_version=”4.27.4″ _module_preset=”5716d3ba-5db9-4c93-9991-e827ac491153″ background_enable_color=”off” custom_padding_tablet=”3rem||3rem||true|false” custom_padding_phone=”2rem||2rem||true|false” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” module_class=”ams-align-items-center” _builder_version=”4.21.0″ _module_preset=”9c599c76-b3a9-46a0-86f3-735203d5c098″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”e6be59c6-62c0-4eac-b5e1-e47041d7be23″ global_colors_info=”{}”][et_pb_image src=”https:\/\/admedsol.com\/wp-content\/uploads\/2023\/10\/MBCP-syringes.png” title_text=”MBCP syringes” _builder_version=”4.22.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”e6be59c6-62c0-4eac-b5e1-e47041d7be23″ global_colors_info=”{}”][et_pb_code _builder_version=”4.24.2″ _module_preset=”default” global_colors_info=”{}”]Synthetic bone grafts with their reliable manufacturing process and the possibility of combining them with bioactive molecules, therapeutic agents and cell for tissue engineering, are an attractive alternative to using patient\u2019s own bone (autograft).<\/pee> There are many synthetic bone sustitute products available, and their properties and behaviour in situ depends on their origin, chemical composition, how they are processed, and the implant site.<\/pee>Addressing the composition, synthetic calcium phosphates are the largest group of artifical bone graft substitutes for their:<\/pee><\/p>\n Close resemblance to the mineral component of bone <\/pee><\/div>\n<\/p>\n
Biocompatibility <\/pee><\/div>\n<\/p>\n
Overall porosity <\/pee><\/div>\n Biphasic Calcium Phosphates (BCP) have been widely used as synthetic alternative to biological bone grafting material in orthopaedic and maxillofacial surgery. They have proved to be a safe, effective and biocompatible scaffold material for the formation of new bone and are an efficient alternative to the gold standard, the autograft.<\/pee>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”ams-bg-gradient-green” _builder_version=”4.27.4″ _module_preset=”5716d3ba-5db9-4c93-9991-e827ac491153″ background_enable_color=”off” custom_padding_tablet=”3rem||3rem||true|false” custom_padding_phone=”2rem||2rem||true|false” locked=”off” global_colors_info=”{}”][et_pb_row module_class=”ams-order-parent” _builder_version=”4.21.0″ _module_preset=”9c599c76-b3a9-46a0-86f3-735203d5c098″ global_colors_info=”{}”][et_pb_column type=”4_4″ module_class=”ams-order-2 ams-mb-0″ _builder_version=”4.21.0″ _module_preset=”e6be59c6-62c0-4eac-b5e1-e47041d7be23″ global_colors_info=”{}”][et_pb_code _builder_version=”4.22.2″ _module_preset=”default” custom_margin=”0rem||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\nHow does synthetic bone substitute work?<\/h3>\n
Bioresorption of calcium phosphate materials is a consequence of physical, chemical, and biological mechanisms that the bone substitute undergoes after implantation. The process of bioresorption is very variable and depends on several factors such as the chemical nature of calcium phosphate ceramics, Hydroxyapatite\/beta-Tricalcium phosphate HA\/\u03b2-TCP ratio, their intrinsic solubility (\u03b2-TCP >>> HA), ionic substitutions or phase impurities, their physical properties such as granulometry, porosity, surface area and crystallinity.<\/pee>Bioresorption also depends on biological factors, such as pH drops due to cell-mediated factors, degree of contact with the bone, health status of the patient and the type of bone. The adequate BCP resorption occurs regularly throughout the implantation period to allow bone formation before the substitute is fully resorbed and maintain the defect volume necessary for bone ingrowth. Indeed, too slow resorption impedes bone remodelling, and too fast resorption reduces mechanical stability and causes fibrous tissue formation instead of osteogenesis.<\/pee>Global porosity<\/pee>An interconnected network of macropores and micropores enables the colonisation of bone cells and exchange biological fluid uniformly within the substitute matrix.<\/pee>Macroporosity describes the interconnected spaces allowing the biological infiltration and cellular colonisation by osteoblasts and osteoclasts, and microporosity allows for the exchange of calcium and phosphate ions into the biological environment. <\/pee>Gradually, the porous material will be completely replaced by new healthy bone.<\/pee>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”5716d3ba-5db9-4c93-9991-e827ac491153″ background_color=”#f9fafb” custom_padding=”6rem||2rem||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.21.0″ _module_preset=”9c599c76-b3a9-46a0-86f3-735203d5c098″ custom_margin=”0rem||2rem||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”e6be59c6-62c0-4eac-b5e1-e47041d7be23″ global_colors_info=”{}”][et_pb_code _builder_version=”4.22.2″ _module_preset=”default” global_colors_info=”{}”]